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Top 6 AS2 Software in 2026

Cem Dilmegani
Cem Dilmegani
updated on Jan 12, 2026

Finding AS2 software that fits your budget and technical needs takes some digging. We’ve narrowed down the options to managed file transfer tools that actually deliver on AS2 support:

Vendors
Rating*
Free Trial
Employee Size
Price
4.6 based on 36 reviews
533
Starting from:
$4,299/One Time
GlobalSCAPE Enhanced File Transfer
4.5 based on 118 reviews
1,741
Not shared publicly
Cleo Integration Cloud
4.4 based on 631 reviews
482
Not shared publicly
WinSCP
4.6 based on 222 reviews
3
Not shared publicly
Axway B2Bi
4.6 based on 281 reviews
90
Not shared publicly
GoAnywhere MFT
4.8 based on 125 reviews
201-500
Not shared publicly
Customers have links and are placed at the top in lists without numerical criteria.

What are our criteria for choosing the top As2 Software? 

  • Real user feedback matters: We prioritized solutions with substantial reviews on G2 and Capterra, where actual users share what works and what doesn’t in their day-to-day operations.
  • Company size indicates stability: We focused on vendors with 50+ employees (based on LinkedIn data). Larger teams typically mean better support, ongoing development, and lower risk of the product disappearing.

JSCAPE MFT

JSCAPE MFT Server handles AS2 transfers with Drummond certification, which means it meets industry standards for encryption, digital signatures, and MDNs (Message Disposition Notifications). The platform also supports OFTP2 for high-speed transfers, which automotive and manufacturing companies use heavily.

JSCAPE MFT server offers:

  • End-to-end encryption on all transfers
  • Multiple authentication options (not just passwords)
  • Workflow automation to reduce manual steps
  • Protocol flexibility: SFTP, FTPS, HTTP/S, and more
  • Audit logs that satisfy compliance teams
  • High availability setups to avoid downtime
  • API access for custom integrations
  • IP whitelisting for tighter security

Files.com

Files.com provides AS2 capabilities through its cloud-based managed file transfer platform. The service handles B2B file exchanges and EDI transmissions without requiring on-premises infrastructure.

What makes it practical:

  • AS2 protocol support for trading partner connections
  • Cloud-native setup (no servers to maintain)
  • EDI file processing alongside standard file transfers
  • Built-in security with encryption and digital signatures
  • Trading partner management through a web interface
  • REST API for custom workflow integration

Files.com fits businesses moving away from legacy on-premises systems or adding AS2 capabilities without hardware investments. Pricing scales based on storage and transfer volume rather than user counts.

Cleo Integration Cloud

Cleo targets logistics, manufacturing, and wholesale operations where B2B file exchanges happen constantly.

The platform gives you visibility into transactions from start to finish, catching errors before they become problems. Both IT and operations teams can use it the low-code interface means you’re not writing scripts for every integration. Pre-built connectors handle common trading partner setups.

Globalscape EFT

Globalscape EFT is distinguished by its workflow automation for secure file transfers. Fortra’s Globalscape Enhanced File Transfer (EFT) enhances operational efficiency and compliance, ensuring the safe exchange of sensitive files.

GlobalSCAPE’s EFT platform uses AS2, among other protocols, to ensure secure data transfers, with non-repudiation and message-integrity checks.

Globalscape EFT Overview

WinSCP

WinSCP focuses on Windows environments and supports SFTP, FTP, WebDAV, and SCP protocols. The interface makes file transfers straightforward for both technical and non-technical users, enabling them to manage without much training.

Scripting capabilities let you automate repetitive tasks. For basic secure file management on Windows, it handles the job without unnecessary complexity.

GoAnywhere MFT

GoAnywhere MFT is a secure file transfer automation software alternative that supports SFTP protocols. It enables users to automate file transfers efficiently and schedule workflows using either its built-in scheduler or existing scheduler software. The browser-based administrator enables the easy execution of authorized projects with a single click, streamlining workflow and file automation.

What are the important features of AS2 Software Solutions?

  • Data Encryption: AS2 software uses standard encryption methods to ensure that data is securely transmitted over the Internet, protecting sensitive information from unauthorized access.
  • Digital Signatures: It employs digital signatures to authenticate the sender of the data, ensuring the integrity and non-repudiation of the transmitted data.
  • Secure and Reliable Transport: AS2 operates over HTTPS, adding an additional layer of security through SSL/TLS. This ensures that data in transit is encrypted and secure from endpoint to endpoint.
  • Interoperability: AS2 software allow for interoperability between different systems and software, facilitating seamless data exchange between businesses regardless of their underlying technologies.
  • Asynchronous and Synchronous Communication: AS2 supports both asynchronous communication, where the response (MDN) is not immediately required and can be sent later, and synchronous communication, where the MDN is sent immediately after the message is received and processed.
  • Payload Agnosticism: AS2 software are not limited to any specific data format, making it versatile for transmitting various types of documents, such as EDI, XML, JSON, binary files, etc.

Source: Advanced Systems Concepts1

Source: AS2 protocol operation 2

FAQ

Further Reading

Principal Analyst
Cem Dilmegani
Cem Dilmegani
Principal Analyst
Cem has been the principal analyst at AIMultiple since 2017. AIMultiple informs hundreds of thousands of businesses (as per similarWeb) including 55% of Fortune 500 every month.

Cem's work has been cited by leading global publications including Business Insider, Forbes, Washington Post, global firms like Deloitte, HPE and NGOs like World Economic Forum and supranational organizations like European Commission. You can see more reputable companies and resources that referenced AIMultiple.

Throughout his career, Cem served as a tech consultant, tech buyer and tech entrepreneur. He advised enterprises on their technology decisions at McKinsey & Company and Altman Solon for more than a decade. He also published a McKinsey report on digitalization.

He led technology strategy and procurement of a telco while reporting to the CEO. He has also led commercial growth of deep tech company Hypatos that reached a 7 digit annual recurring revenue and a 9 digit valuation from 0 within 2 years. Cem's work in Hypatos was covered by leading technology publications like TechCrunch and Business Insider.

Cem regularly speaks at international technology conferences. He graduated from Bogazici University as a computer engineer and holds an MBA from Columbia Business School.
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Researched by
Sena Sezer
Sena Sezer
Industry Analyst
Sena is an industry analyst in AIMultiple. She completed her Bachelor's from Bogazici University.
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